Effectiveness and toxicity of hypofractionated high-dose intensity-modulated radiotherapy versus 2- and 3-dimensional radiotherapy in incurable head and neck cancer
SourceHead and Neck-Journal for the Sciences and Specialties of the Head and Neck, 38 Suppl 1, (2016), pp. E1264-70
Article / Letter to editor
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Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
vol. 38 Suppl 1
SubjectRadboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
BACKGROUND: This retrospective study evaluates efficacy and tolerability of high-dose hypofractionated radiotherapy (RT) in patients with head and neck cancer. METHODS: All patients with head and neck cancer treated between September 2003 and September 2013 with 12 x 4 Gy RT were included. Two and 3D-RT or intensity-modulated radiotherapy (IMRT) were used. Overall survival (OS), tumor response, and palliative effect were evaluated. RESULTS: Palliative effect occurred in 63% of 81 included patients, lasted a median of 4.6 months, and was correlated with tumor response (p = .006). Median OS was 7.2 months. Confluent mucositis occurred more often in patients treated with 2D/3D-RT than IMRT (26% vs 44%; p = .04) and lasted for a median of 2 weeks. CONCLUSION: High-dose hypofractionated RT resulted in meaningful palliation in 63%, lasting for almost 5 months. IMRT should be the technique of choice, as it results in less high-grade toxicity. The 12 x 4 schedule should be opted for patients with reasonable functional capacities and a life expectancy of >6 months. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: E1264-E1270, 2016.
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