A preliminary study searching for the right dose of tacrolimus in very young (</=4 years) renal transplant patients
SourceJournal of Pharmacy and Pharmacology, 68, 11, (2016), pp. 1366-1372
Article / Letter to editor
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Paediatrics - OUD tm 2017
Journal of Pharmacy and Pharmacology
SubjectRadboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences
OBJECTIVES: The Radboudumc Amalia Children's hospital in the Netherlands has a programme for renal transplantation in children aged </=4 years. Children receive chronic corticosteroid sparing immunosuppressive therapy that consists of tacrolimus and mycophenolate mofetil. This work aimed to describe the PK of tacrolimus in children </=4 years with renal transplants. METHODS: Paediatric renal transplant patients aged </=4 years were included in this analysis. A PK curve of tacrolimus recorded </=3 weeks after transplantation has been standard of care in our institution and aided in adjusting the dose in each patient to attain a target AUC0-12h of 210 mug h/l early after transplantation. KEY FINDINGS: Eight patients were included. The first two patients received an initial twice-daily regimen and the subsequent six patients a three-times daily regimen. Median dose-corrected AUCtau was 63 mug h/l. AUC target attainment was 37.5%. Of the remaining patients, two had an AUC very close to (around 10% below) the target. CONCLUSIONS: Large interindividual variability of tacrolimus was observed and showed suboptimal AUC target attainment. In this population, an even more aggressive approach of higher doses (e.g. 0.4 mg/kg per day) and more early AUC determination should be considered. This should be evaluated prospectively in a larger group of patients.
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