Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review

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Title:	Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review
Author(s):	Hellquist, H.; Skalova, A.; Barnes, L.; Cardesa, A.; Thompson, L.D.; Triantafyllou, A.; Williams, M.D.; Devaney, K.O.; Gnepp, D.R.; Bishop, J.A.; Wenig, B.M.; Suarez, C.; Rodrigo, J.P.; Coca-Pelaz, A.; Strojan, P.; Shah, J.P.; Hamoir, M.; Bradley, P.J.; Silver, C.E.; Slootweg, P.J. ; Poorten, V. Van der; Teymoortash, A.; Medina, J.E.; Robbins, K.T.; Pitman, K.T.; Kowalski, L.P.; Bree, R. de; Mendenhall, W.M.; Eloy, J.A.; Takes, R.P. ; Rinaldo, A.; Ferlito, A.
Publication year:	2016
Source:	Advances in Therapy, vol. 33, iss. 3, (2016), pp. 357-368
ISSN:	0741-238X
DOI:	https://doi.org/10.1007/s12325-016-0298-5
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/172098
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Subject:	Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Pathology Otorhinolaryngology
Journal title:	Advances in Therapy
Volume:	vol. 33
Issue:	iss. 3
Page start:	p. 357
Page end:	p. 368
Abstract:	Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.