Visualisation of newly synthesised collagen in vitro and in vivo
Publication year
2016Source
Scientific Reports, 6, (2016), article 18780ISSN
Publication type
Article / Letter to editor
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Organization
Biochemistry (UMC)
Dermatology
Urology
Dentistry
Journal title
Scientific Reports
Volume
vol. 6
Subject
Radboudumc 10: Reconstructive and regenerative medicine RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 15: Urological cancers RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 5: Inflammatory diseases RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Identifying collagen produced de novo by cells in a background of purified collagenous biomaterials poses a major problem in for example the evaluation of tissue-engineered constructs and cell biological studies to tumor dissemination. We have developed a universal strategy to detect and localize newly deposited collagen based on its inherent association with dermatan sulfate. The method is applicable irrespective of host species and collagen source.
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- Academic publications [238441]
- Electronic publications [122537]
- Faculty of Medical Sciences [90373]
- Open Access publications [97530]
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