The NLRP1-IL18 Connection: A Stab in the Back of Obesity-Induced Inflammation
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SourceCell Metabolism, 23, 1, (2016), pp. 6-7
Article / Letter to editor
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SubjectRadboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
IL-18 has been reported to counteract obesity and metabolic syndrome, though the underlying mechanisms remain unclear. In this issue, Masters and colleagues describe how NLRP1 inflammasome induces IL-18 production in fat, solving not only an important biological mechanism, but also opening the door for therapeutic approaches (Murphy et al., 2016).
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