Stabilization of protein-protein interaction complexes through small molecules

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Title:	Stabilization of protein-protein interaction complexes through small molecules
Author(s):	Zarzycka, B.; Kuenemann, M.A.; Miteva, M.A.; Nicolaes, G.A.; Vriend, G. ; Sperandio, O.
Publication year:	2016
Source:	Drug Discovery Today, vol. 21, iss. 1, (2016), pp. 48-57
ISSN:	1359-6446
DOI:	https://doi.org/10.1016/j.drudis.2015.09.011
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/171532
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Subject:	Radboudumc 19: Nanomedicine RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	CMBI
Journal title:	Drug Discovery Today
Volume:	vol. 21
Issue:	iss. 1
Page start:	p. 48
Page end:	p. 57
Abstract:	Most of the small molecules that have been identified thus far to modulate protein-protein interactions (PPIs) are inhibitors. Another promising way to interfere with PPI-associated biological processes is to promote PPI stabilization. Even though PPI stabilizers are still scarce, stabilization of PPIs by small molecules is gaining momentum and offers new pharmacological options. Therefore, we have performed a literature survey of PPI stabilization using small molecules. From this, we propose a classification of PPI stabilizers based on their binding mode and the architecture of the complex to facilitate the structure-based design of stabilizers.