Publication year
2016Source
Drug Discovery Today, 21, 1, (2016), pp. 48-57ISSN
Publication type
Article / Letter to editor

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Organization
CMBI
Journal title
Drug Discovery Today
Volume
vol. 21
Issue
iss. 1
Page start
p. 48
Page end
p. 57
Subject
Radboudumc 19: Nanomedicine RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Most of the small molecules that have been identified thus far to modulate protein-protein interactions (PPIs) are inhibitors. Another promising way to interfere with PPI-associated biological processes is to promote PPI stabilization. Even though PPI stabilizers are still scarce, stabilization of PPIs by small molecules is gaining momentum and offers new pharmacological options. Therefore, we have performed a literature survey of PPI stabilization using small molecules. From this, we propose a classification of PPI stabilizers based on their binding mode and the architecture of the complex to facilitate the structure-based design of stabilizers.
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- Academic publications [202802]
- Faculty of Medical Sciences [80020]
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