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Title: Salivary acinic cell carcinoma: reappraisal and update
Author(s): Poorten, V. Van der; Triantafyllou, A.; Thompson, L.D.; Bishop, J.; Hauben, E.; Hunt, J.; Skalova, A.; Stenman, G.; Takes, R.P. ; Gnepp, D.R.; Hellquist, H.; Wenig, B.; Bell, D.; Rinaldo, A.; Ferlito, A.
Publication year: 2016
Source: European Archives of Oto-Rhino-Laryngology, vol. 273, iss. 11, (2016), pp. 3511-3531
ISSN: 0937-4477
DOI: https://doi.org/10.1007/s00405-015-3855-7
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/171459   http://hdl.handle.net/2066/171459

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Subject: Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Organization: Otorhinolaryngology
Journal title:
European Archives of Oto-Rhino-Laryngology
Volume: vol. 273
Issue: iss. 11
Page start: p. 3511
Page end: p. 3531
Abstract:
Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

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