Salivary acinic cell carcinoma: reappraisal and update
until further notice
SourceEuropean Archives of Oto-Rhino-Laryngology, 273, 11, (2016), pp. 3511-3531
Article / Letter to editor
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European Archives of Oto-Rhino-Laryngology
SubjectRadboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.
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