Quantitative Ultrasound for Staging of Hepatic Steatosis in Patients on Home Parenteral Nutrition Validated with Magnetic Resonance Spectroscopy: A Feasibility Study

Fulltext:
171319.pdf
Embargo:
until further notice
Size:
579.7Kb
Format:
PDF
Description:
publisher's version
Publication year
2016Source
Ultrasound in Medicine and Biology, 42, 3, (2016), pp. 637-44ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Medical Imaging
Gastroenterology
Internal Medicine
Paediatrics - OUD tm 2017
Journal title
Ultrasound in Medicine and Biology
Volume
vol. 42
Issue
iss. 3
Page start
p. 637
Page end
p. 44
Subject
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Patients on home parenteral nutrition are at risk for developing liver dysfunction, which is due partly to the accumulation of lipids in the liver (steatosis) and may progress to end-stage liver disease with overt liver failure. Therefore, a timely diagnosis with easy access to repeated assessment of the degree of liver steatosis is of great importance. A pilot study was performed in 14 patients on long-term home parenteral nutrition using the computer-aided ultrasound method. Ultrasound radio frequency data were acquired using a phased array transducer and were converted into conventional B-mode images. All patients were subjected to proton magnetic resonance spectroscopy measurement of liver fat content for reference. Computer-aided ultrasound parameters similar to those in a previous validation study in cows revealed significant correlations with fat content measured by magnetic resonance spectroscopy. The most significant parameters were the residual attenuation coefficient (R = 0.95, p < 0.001) and the lateral speckle size (R = 0.77, p = 0.021). These findings indicate the potential usefulness of computer-aided ultrasound for staging of hepatic steatosis.
This item appears in the following Collection(s)
- Academic publications [204981]
- Electronic publications [103240]
- Faculty of Medical Sciences [81051]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.