Neuroendocrine neoplasms of the sinonasal region

There is no fulltext present in this item.

Title:	Neuroendocrine neoplasms of the sinonasal region
Author(s):	Bell, D.; Hanna, E.Y.; Weber, R.S.; DeMonte, F.; Triantafyllou, A.; Lewis, J.S., Jr.; Cardesa, A.; Slootweg, P.J. ; Stenman, G.; Gnepp, D.R.; Devaney, K.O.; Rodrigo, J.P.; Rinaldo, A.; Wenig, B.M.; Westra, W.H.; Bishop, J.A.; Hellquist, H.; Hunt, J.L.; Kusafuka, K.; Perez-Ordonez, B.; Williams, M.D.; Takes, R.P. ; Ferlito, A.
Publication year:	2016
Source:	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, vol. 38 Suppl 1, (2016), pp. E2259-66
ISSN:	1043-3074
DOI:	https://doi.org/10.1002/hed.24152
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/171033
Display more details
Subject:	Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Pathology Otorhinolaryngology
Journal title:	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume:	vol. 38 Suppl 1
Page start:	p. E2259
Page end:	p. 66
Abstract:	Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: E2259-E2266, 2016.