Publication year
2016Author(s)
Source
Head and Neck : Journal for the Sciences and Specialties of the Head and Neck, 38 Suppl 1, (2016), pp. E2259-66ISSN
Publication type
Article / Letter to editor

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Organization
Pathology
Otorhinolaryngology
Journal title
Head and Neck : Journal for the Sciences and Specialties of the Head and Neck
Volume
vol. 38 Suppl 1
Page start
p. E2259
Page end
p. 66
Subject
Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: E2259-E2266, 2016.
This item appears in the following Collection(s)
- Academic publications [227864]
- Faculty of Medical Sciences [86218]
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