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Title: Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: where are we?
Author(s): Samuels, S.E.; Eisbruch, A.; Beitler, J.J.; Corry, J.; Bradford, C.R.; Saba, N.F.; Brekel, M.W. van den; Smee, R.; Strojan, P.; Suarez, C.; Mendenhall, W.M.; Takes, R.P. ; Rodrigo, J.P.; Haigentz, M., Jr.; Rapidis, A.D.; Rinaldo, A.; Ferlito, A.
Publication year: 2016
Source: European Archives of Oto-Rhino-Laryngology, vol. 273, iss. 10, (2016), pp. 2877-2894
ISSN: 0937-4477
DOI: https://doi.org/10.1007/s00405-015-3771-x
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/170923   http://hdl.handle.net/2066/170923

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Subject: Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Organization: Otorhinolaryngology
Journal title:
European Archives of Oto-Rhino-Laryngology
Volume: vol. 273
Issue: iss. 10
Page start: p. 2877
Page end: p. 2894
Abstract:
HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV-) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.

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