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Publication year
2016Source
European Archives of Oto-Rhino-Laryngology, 273, 10, (2016), pp. 2877-94ISSN
Publication type
Article / Letter to editor

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Organization
Otorhinolaryngology
Journal title
European Archives of Oto-Rhino-Laryngology
Volume
vol. 273
Issue
iss. 10
Page start
p. 2877
Page end
p. 94
Subject
Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health SciencesAbstract
HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV-) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.
This item appears in the following Collection(s)
- Academic publications [227881]
- Electronic publications [107344]
- Faculty of Medical Sciences [86219]
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