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Title: Acute Kidney Injury After Efavirenz/Tenofovir Disoproxil Fumarate/Emtricitabine (Atripla) Overdose
Author(s): Havenith, T.; Burger, D.M. ; Visschers, M.J.; Schippers, J.; Lashof, A.O.
Publication year: 2017
Source: Therapeutic Drug Monitoring, vol. 39, iss. 2, (2017), pp. 91-92
ISSN: 0163-4356
DOI: http://dx.doi.org/10.1097/FTD.0000000000000386
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/169765   http://hdl.handle.net/2066/169765

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Subject: Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health Sciences
Organization: Clinical Pharmacy
Journal title:
Therapeutic Drug Monitoring
Volume: vol. 39
Issue: iss. 2
Page start: p. 91
Page end: p. 92
Abstract:
We describe a patient with acute renal failure and irreversible kidney damage after an overdose with the fixed dose combination of efavirenz/tenofovir disoproxil fumarate/emtricitabine (Atripla). The acute kidney injury was most probably caused by tenofovir. Efavirenz and emtricitabine seemed relatively safe in overdose. The pharmacokinetics in overdose of all 3 drugs and the effect of hemodialysis on the tenofovir clearance were studied by measuring the plasma concentrations and by the use of clinical pharmacokinetic software.

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