Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
SourceNature Communications, 8, (2017), pp. 14694
Article / Letter to editor
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SubjectRadboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 x 10-8, METAL) of which 23 have not been reported previously. The 63 loci explain approximately 39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.
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