Inside view of a giant proton pump
SourceAngewandte Chemie. International Edition, 52, 29, (2013), pp. 7358-7360
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
Paediatrics - OUD tm 2017
Angewandte Chemie. International Edition
SubjectIGMD 8: Mitochondrial medicine; IGMD 8: Mitochondrial medicine NCMLS 4: Energy and redox metabolism; IGMD 8: Mitochondrial medicine NCMLS 4: Energy and redox metabolism
Inner workings: The X-ray crystal structure of the entire bacterial complex I at 3.3 A resolution offers fascinating insights into a giant 536 kDa molecular machine. The respiratory chain complex seems to employ unique mechanisms of energetic coupling that are entirely different from those found in all other enzymes using redox energy to drive vectorial proton transport across a bioenergetic membrane.
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