The Multifarious Hippocampal Functions of MicroRNA-137
until further notice
SourceNeuroscientist, 22, 5, (2016), pp. 440-6
Article / Letter to editor
Display more detailsDisplay less details
SubjectNeuroinformatics; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
MicroRNAs (miRs) have emerged as a powerful class of endogenous noncoding RNAs involved in posttranscriptional gene expression regulation. miR-137 has repeatedly been associated with schizophrenia and intellectual disability. Recent studies describe the mechanisms of miR-137 in mediating basic synaptic transmission and plasticity in the hippocampus. A picture is emerging in which miR-137 acts as a potent player in regulating glutamatergic synaptic transmission in the hippocampus by controlling the translation of functionally critical genes at spatially opposite ends of the synapse, contributing to the pathogenesis of cognitive impairments as seen in neurodevelopmental disorders.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.