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Title: Sudden Death: An Uncommon Occurrence in Dementia with Lewy Bodies
Author(s): Molenaar, J.P.; Wilbers, J. ; Aerts, M.B. ; Leijten, Q.H.; Dijk, J.G. van; Esselink, R.A. ; Bloem, B.R.
Publication year: 2016
Source: Journal of Parkinson's Disease, vol. 6, iss. 1, (2016), pp. 53-55
ISSN: 1877-7171
DOI: https://doi.org/10.3233/JPD-150755
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/168163   http://hdl.handle.net/2066/168163

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Subject: Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience
Organization: Neurology
Journal title:
Journal of Parkinson's Disease
Volume: vol. 6
Issue: iss. 1
Page start: p. 53
Page end: p. 55
Abstract:
We present a 75-year-old woman with dementia and parkinsonism who developed severe orthostatic hypotension and eventually died. Autopsy revealed extensive Lewy body formation in the midbrain, limbic system, intermediate spinal cord, and medulla oblongata. Furthermore, a vast amount of Lewy bodies was seen in the paravertebral sympathetic ganglia which likely explained the severe autonomic failure. We speculate that this autonomic failure caused sudden death through dysregulation of respiration or heart rhythm, reminiscent of sudden death in multiple system atrophy (MSA). Clinicians should be aware of this complication in patients presenting with parkinsonism and autonomic dysfunction, and that sudden death may occur in dementia with Lewy bodies (DLB) as it does in MSA.

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