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Publication year
2016Source
Journal of Parkinson's Disease, 6, 1, (2016), pp. 53-55ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Journal title
Journal of Parkinson's Disease
Volume
vol. 6
Issue
iss. 1
Page start
p. 53
Page end
p. 55
Subject
Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical NeuroscienceAbstract
We present a 75-year-old woman with dementia and parkinsonism who developed severe orthostatic hypotension and eventually died. Autopsy revealed extensive Lewy body formation in the midbrain, limbic system, intermediate spinal cord, and medulla oblongata. Furthermore, a vast amount of Lewy bodies was seen in the paravertebral sympathetic ganglia which likely explained the severe autonomic failure. We speculate that this autonomic failure caused sudden death through dysregulation of respiration or heart rhythm, reminiscent of sudden death in multiple system atrophy (MSA). Clinicians should be aware of this complication in patients presenting with parkinsonism and autonomic dysfunction, and that sudden death may occur in dementia with Lewy bodies (DLB) as it does in MSA.
This item appears in the following Collection(s)
- Academic publications [202606]
- Electronic publications [100803]
- Faculty of Medical Sciences [79948]
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