Does the cognitive architecture of simplex and multiplex ASD families differ?
Publication year
2016Source
Journal of Autism and Developmental Disorders, 46, 2, (2016), pp. 489-501ISSN
Publication type
Article / Letter to editor
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Organization
Cognitive Neuroscience
Human Genetics
Psychiatry
Journal title
Journal of Autism and Developmental Disorders
Volume
vol. 46
Issue
iss. 2
Page start
p. 489
Page end
p. 501
Subject
Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical NeuroscienceAbstract
Children with an autism spectrum disorder (ASD) and their unaffected siblings from 54 simplex (SPX, one individual in the family affected) and 59 multiplex (MPX, two or more individuals affected) families, and 124 controls were assessed on intelligence, social cognition and executive functions. SPX and MPX ASD probands displayed similar cognitive profiles, but within-family contrasts were highest in SPX families, suggesting SPX-MPX stratification may help parse etiological heterogeneity of ASD. Unaffected siblings (regardless SPX or MPX) were mostly unimpaired, suggesting that cognitive problems may be part of the defining features of ASD, rather than being an endophenotypic trait. Except for affective prosody, which appeared to be the most sensitive cognitive marker for detecting familial risk for ASD.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122518]
- Faculty of Medical Sciences [90373]
- Open Access publications [97513]
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