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Publication year
2016Author(s)
Number of pages
11 p.
Source
Human Brain Mapping, 37, 1, (2016), pp. 327-337ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
PI Group MR Techniques in Brain Function
Geriatrics
Medical Psychology
SW OZ DCC NRP
Journal title
Human Brain Mapping
Volume
vol. 37
Issue
iss. 1
Languages used
English (eng)
Page start
p. 327
Page end
p. 337
Subject
Biophysics; DI-BCB_DCC_Theme 3: Plasticity and Memory; Neuropsychology and rehabilitation psychology; Radboudumc 1: Alzheimer`s disease DCMN: Donders Center for Medical Neuroscience; Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience; Neuro- en revalidatiepsychologieAbstract
INTRODUCTION: Cerebral small vessel disease is one of the most important risk factors for dementia, and has been related to hippocampal atrophy, which is among the first observed changes on conventional MRI in patients with dementia. However, these volumetric changes might be preceded by loss of microstructural integrity of the hippocampus for which conventional MRI is not sensitive enough. Therefore, we investigated the relation between the hippocampal diffusion parameters and the risk of incident dementia, using diffusion tensor imaging, independent of hippocampal volume. METHODS: The RUNDMC study is a prospective study among 503 elderly with small vessel disease, without dementia, with 5 years follow-up in 2012 (99.6% response-rate). Cox regression analysis was performed to calculate hazard ratios for dementia, of fractional anisotropy and mean diffusivity within the hippocampus, adjusted for demographics, hippocampal volume, and white matter. This was repeated in participants without evident hippocampal volume loss, because in these participants the visible damage might not yet have already started, whereas damage might have started on a microstructural level. RESULTS: 43 participants developed dementia (8.6%), resulting in a 5.5-year cumulative risk of 11.1% (95%CI 7.7-14.6). Higher mean diffusivity was associated with an increased 5-year risk of dementia. In the subgroup of participants with the upper half hippocampal volume, higher hippocampal mean diffusivity, more than doubled the 5-year risk of dementia. CONCLUSION: This is the first prospective study showing a relation between a higher baseline hippocampal mean diffusivity and the risk of incident dementia in elderly with small vessel disease at 5-year follow-up, independent of hippocampal volume and white matter volume. Hum Brain Mapp 37:327-337, 2016. (c) 2015 Wiley Periodicals, Inc.
This item appears in the following Collection(s)
- Academic publications [227693]
- Donders Centre for Cognitive Neuroimaging [3564]
- Electronic publications [107311]
- Faculty of Medical Sciences [86198]
- Faculty of Social Sciences [28418]
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