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Title: Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies
Author(s): Brouwer, M.; Zhou, Huiqing ; Nadif Kasri, N.
Publication year: 2016
Source: Stem Cell Reviews and Reports, vol. 12, iss. 1, (2016), pp. 54-72
ISSN: 1550-8943
DOI: http://dx.doi.org/10.1007/s12015-015-9622-8
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/167649   http://hdl.handle.net/2066/167649

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Subject: Radboudumc 10: Reconstructive and regenerative medicine RIMLS: Radboud Institute for Molecular Life Sciences
Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience
Organization: Human Genetics
Journal title:
Stem Cell Reviews and Reports
Volume: vol. 12
Issue: iss. 1
Page start: p. 54
Page end: p. 72
Abstract:
The ability to generate human induced pluripotent stem cells (iPSCs) from somatic cells provides tremendous promises for regenerative medicine and its use has widely increased over recent years. However, reprogramming efficiencies remain low and chromosomal instability and tumorigenic potential are concerns in the use of iPSCs, especially in clinical settings. Therefore, reprogramming methods have been under development to generate safer iPSCs with higher efficiency and better quality. Developments have mainly focused on the somatic cell source, the cocktail of reprogramming factors, the delivery method used to introduce reprogramming factors and culture conditions to maintain the generated iPSCs. This review discusses the developments on these topics and briefly discusses pros and cons of iPSCs in comparison with human embryonic stem cells generated from somatic cell nuclear transfer.

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