Abnormal connectivity in the sensorimotor network predicts attention deficits in traumatic brain injury
Publication year
2017Number of pages
9 p.
Source
Experimental Brain Research, 235, 3, (2017), pp. 799-807ISSN
Publication type
Article / Letter to editor

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Organization
PI Group MR Techniques in Brain Function
Human Genetics
SW OZ DCC AI
SW OZ DCC NRP
Medical Psychology
Journal title
Experimental Brain Research
Volume
vol. 235
Issue
iss. 3
Languages used
English (eng)
Page start
p. 799
Page end
p. 807
Subject
150 000 MR Techniques in Brain Function; Biophysics; Cognitive artificial intelligence; DI-BCB_DCC_Theme 3: Plasticity and Memory; DI-BCB_DCC_Theme 4: Brain Networks and Neuronal Communication; Neuropsychology and rehabilitation psychology; Radboudumc 1: Alzheimer`s disease DCMN: Donders Center for Medical Neuroscience; Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience; Neuro- en revalidatiepsychologieAbstract
The aim of this study was to explore modifications of functional connectivity in multiple resting-state networks (RSNs) after moderate to severe traumatic brain injury (TBI) and evaluate the relationship between functional connectivity patterns and cognitive abnormalities. Forty-three moderate/severe TBI patients and 34 healthy controls (HC) underwent resting-state fMRI. Group ICA was applied to identify RSNs. Between-subject analysis was performed using dual regression. Multiple linear regressions were used to investigate the relationship between abnormal connectivity strength and neuropsychological outcome. Forty (93%) TBI patients showed moderate disability, while 2 (5%) and 1 (2%) upper severe disability and low good recovery, respectively. TBI patients performed worse than HC on the domains attention and language. We found increased connectivity in sensorimotor, visual, default mode (DMN), executive, and cerebellar RSNs after TBI. We demonstrated an effect of connectivity in the sensorimotor RSN on attention (p < 10-3) and a trend towards a significant effect of the DMN connectivity on attention (p = 0.058). A group-by-network interaction on attention was found in the sensorimotor network (p = 0.002). In TBI, attention was positively related to abnormal connectivity within the sensorimotor RSN, while in HC this relation was negative. Our results show altered patterns of functional connectivity after TBI. Attention impairments in TBI were associated with increased connectivity in the sensorimotor network. Further research is needed to test whether attention in TBI patients is directly affected by changes in functional connectivity in the sensorimotor network or whether the effect is actually driven by changes in the DMN.
This item appears in the following Collection(s)
- Academic publications [227437]
- Donders Centre for Cognitive Neuroimaging [3564]
- Electronic publications [107154]
- Faculty of Medical Sciences [86157]
- Faculty of Social Sciences [28417]
- Open Access publications [76292]
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