Coeliac disease and reproductive disorders: a neglected association.
SourceEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 96, 2, (2001), pp. 146--9
Article / Letter to editor
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European Journal of Obstetrics & Gynecology and Reproductive Biology
SubjectEpidemiology; Prevention of disorders in human reproduction: (Patho)Physiological, endocrinological and methabolic aspects; Epidemiologie; Preventie van stoornissen in de menselijke voortplanting: (Patho-)fysiologische, endocriene en metabole aspecten.
Coeliac disease is a chronic disease caused by a permanent intolerance to ingested gluten resulting in immunologically mediated inflammatory damage of the small-intestinal mucosa. The wide spectrum of clinical symptoms is partly due to the malnourished state caused by the malabsorption of macro- and micronutrients. Fertility problems, sexual dysfunction and obstetrical complications are more frequently observed in patients with coeliac disease. These reproductive disorders may be a consequence of the endocrine derangements caused by selective nutrient deficiencies. Nowadays, the early diagnosis and treatment of coeliac disease is possible and not very costly. Therefore, coeliac disease must be seriously considered in the preconceptional screening and treatment of patients with reproductive disorders.
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