Decreased relative brain tissue levels of inositol in fetal hydrocephalus.

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Title:	Decreased relative brain tissue levels of inositol in fetal hydrocephalus.
Author(s):	Kok, R.D. ; Steegers-Theunissen, R.P.M. ; Eskes, T.K.A.B. ; Heerschap, A. ; Berg, P.P. van den
Publication year:	2003
Source:	American Journal of Obstetrics and Gynecology, vol. 188, iss. 4, (2003), pp. 978-980
ISSN:	0002-9378
DOI:	https://doi.org/10.1067/mob.2003.206
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/166795
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Subject:	EBP 1: Determinants in Health and Disease EBP 2: Effective Hospital Care UMCN 1.1: Functional Imaging UMCN 1.5: Interventional oncology UMCN 5.2: Endocrinology and reproduction
Organization:	Gynaecology Radiology
Journal title:	American Journal of Obstetrics and Gynecology
Volume:	vol. 188
Issue:	iss. 4
Page start:	p. 978
Page end:	p. 980
Abstract:	OBJECTIVE: Inositol seems to play a role in the development of the central nervous system. In this study, the brain tissue level of inositol in fetal hydrocephalus was compared with that of healthy control subjects. STUDY DESIGN: Proton magnetic resonance spectroscopy was used to examine the inositol over creatine ratio in the brain of 10 hydrocephalic human fetuses and 36 normal control subjects. RESULTS: Resolved signals for inositol and creatine were detected successfully in six hydrocephalic fetuses and in all control subjects. The inositol over creatine ratio was significantly lower in fetuses with hydrocephalus (P <.01). CONCLUSION: This result supports speculations concerning the role of inositol in central nervous system development.