C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration.

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Title:	C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration.
Author(s):	Ebisch, I.M.W.; Heerde, W.L. van ; Thomas, C.M.G. ; Put, N.M.J. van der ; Wong, W.Y. ; Steegers-Theunissen, R.P.M.
Publication year:	2003
Source:	Fertility and Sterility, vol. 80, iss. 5, (2003), pp. 1190-1194
ISSN:	0015-0282
DOI:	http://dx.doi.org/10.1016/S0015-0282(03)02157-5
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/166784
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Subject:	EBP 1: Determinants in Health and Disease EBP 2: Effective Hospital Care UMCN 1.5: Interventional oncology UMCN 2.2: Vascular medicine and diabetes UMCN 5.2: Endocrinology and reproduction
Organization:	Gynaecology CHL Chemical Endocrinology Paediatrics
Journal title:	Fertility and Sterility
Volume:	vol. 80
Issue:	iss. 5
Page start:	p. 1190
Page end:	p. 1194
Abstract:	OBJECTIVE: To determine the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism in fertile and subfertile males, and the MTHFR-dependent response of sperm concentration after folic acid and/or zinc sulfate intervention. DESIGN: Double-blind, placebo-controlled intervention study.Two outpatient fertility clinics and nine midwifery practices in The Netherlands. PATIENT(S): One hundred thirteen fertile and 77 subfertile males.Daily capsules of folic acid (5 mg) and/or zinc sulfate (66 mg), or placebo for 26 weeks. MAIN OUTCOME MEASURE(S): Prevalence of C677T MTHFR polymorphism and the response of sperm concentration related to MTHFR carriership after intervention treatment. RESULT(S): The C677T methylenetetrahydrofolate reductase genotypes were comparable in fertile and subfertile males. Independent of fertility state, sperm concentration significantly increased in wild-types after folic acid and zinc sulfate treatment only. Heterozygotes and homozygotes did not significantly benefit from either treatment. CONCLUSION(S):C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for male factor subfertility. In contrast to heterozygotes and homozygotes for C677T MTHFR polymorphism, sperm concentration in wild-types significantly improved after folic acid and zinc sulfate intervention. A stronger role of other folate genes on spermatogenesis is suggested.