Publication year
2002Source
Nederlands Tijdschrift voor Geneeskunde, 146, 37, (2002), pp. 1724-1729ISSN
Publication type
Article / Letter to editor

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Organization
Neurology
Radiation Oncology
Neurosurgery
Medical Oncology
Journal title
Nederlands Tijdschrift voor Geneeskunde
Volume
vol. 146
Issue
iss. 37
Page start
p. 1724
Page end
p. 1729
Subject
Experimental diagnostics and therapy of malignancies; Experimental radiotherapy and neuro-oncology.; Pathophysiology of Brain and Behaviour; Experimentele radiotherapie en neuro-oncologie.; Onderzoek Neurochirurgie; Pathofysiologie van Hersenen en GedragAbstract
Patients with cancer have a 15 to 30% risk of developing symptomatic brain metastases. The prognosis is extremely poor then: the median survival period is less than one year. Treatment strategies aim to guarantee an optimal quality of life. Curative treatment can only be given in just a few unique cases. Besides the previous standard treatment of whole-brain radiotherapy, the efficacy of other treatment modalities as surgery, radiosurgery, and systemic chemotherapy has been demonstrated to have additional value for certain indications. Important factors that play a role in the decision to give a specific treatment are the age and performance status of the patient, the number of brain metastases and their location, the systemic tumour activity, and the radiosensitivity and chemosensitivity of the primary tumour. A multidisciplinary approach is necessary to guarantee an optimal treatment plan.
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- Faculty of Medical Sciences [80326]
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