[Reduced risk of stroke recurrence due to hypotensive medication, irrespective of the initial blood pressure]
Publication year
2002Source
Nederlands Tijdschrift voor Geneeskunde, 146, 9, (2002), pp. 398-9ISSN
Publication type
Article / Letter to editor
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Organization
Internal Medicine
Journal title
Nederlands Tijdschrift voor Geneeskunde
Volume
vol. 146
Issue
iss. 9
Page start
p. 398
Page end
p. 9
Subject
Hypertension and Circulation; Hypertensie en circulatieAbstract
The 'Perindopril protection against recurrent stroke study' (PROGRESS) demonstrated that for patients with a history of stroke or transient ischaemic attack during the previous 5 years, a blood-pressure-lowering regimen based on the combination of a diuretic and an angiotensin-converting enzyme (ACE) inhibitor, reduces the risk of stroke recurrence (fatal and non-fatal) by 28% (95%-CI: 17-38). This effect was irrespective of the initial neurological diagnosis (ischaemic or haemorrhagic stroke) and blood pressure level. Patients who were treated with just the ACE inhibitor did not exhibit these effects. This large-scale clinical trial demonstrates that hypotensive medication in the form of a diuretic combined with an ACE inhibitor is a beneficial strategy for the secondary prevention of stroke in normotensive and hypertensive patients.
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- Faculty of Medical Sciences [93208]
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