The association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-injuries
Publication year
2017Author(s)
Number of pages
8 p.
Source
Behavior Genetics, 47, 1, (2017), pp. 3-10ISSN
Publication type
Article / Letter to editor

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Organization
SW OZ BSI OGG
Journal title
Behavior Genetics
Volume
vol. 47
Issue
iss. 1
Languages used
English (eng)
Page start
p. 3
Page end
p. 10
Subject
Developmental PsychopathologyAbstract
Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.
This item appears in the following Collection(s)
- Academic publications [227437]
- Electronic publications [107154]
- Faculty of Social Sciences [28417]
- Open Access publications [76295]
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