Publication year
2001Source
Journal of Biomedical Materials Research, 56, 2, (2001), pp. 208--15ISSN
Publication type
Article / Letter to editor
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Organization
Periodontology and Biomaterials
Radboudumc Extern
Journal title
Journal of Biomedical Materials Research
Volume
vol. 56
Issue
iss. 2
Page start
p. 208-
Page end
p. 15
Subject
Implantology and biomaterials; Implantologie en biomaterialenAbstract
A new biomimetic method for coating metal implants enables the fast formation of dense and homogeneous calcium phosphate coatings. Titanium alloy (Ti6Al4V) disks were coated with a thin, carbonated, amorphous calcium phosphate (ACP) by immersion in a saturated solution of calcium, phosphate, magnesium, and carbonate. The ACP-coated disks then were processed further by incubation in calcium phosphate solutions to produce either crystalline carbonated apatite (CA) or octacalcium phosphate (OCP). The resorption behavior of these three biomimetic coatings was studied using osteoclast-enriched mouse bone-marrow cell cultures for 7 days. Cell-mediated degradation was observed for both carbonated apatite and octacalcium phosphate coatings. Numerous resorption lacunae characteristic of osteoclastic resorption were found on carbonated apatite after cell culture. The results showed that carbonated apatite coatings are resorbed by osteoclasts in a manner consistent with normal osteoclastic resorption. Osteoclasts also degraded the octacalcium phosphate coatings but not by classical pit formation.
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- Academic publications [245050]
- Faculty of Medical Sciences [93209]
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