The use of bisphosphonates for bone-specific drug delivery
[S.l.] : [S.n.]
Radboud University, 10 november 2016
Promotor : Jansen, J.A. Co-promotor : Leeuwenburgh, S.C.G.
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SubjectRadboudumc 10: Reconstructive and regenerative medicine RIMLS: Radboud Institute for Molecular Life Sciences
The pharmacological efficacy of conventional drug formulations can be improved through the use of drug delivery systems. Controlled drug delivery systems are intended to deliver drugs locally at predetermined rates for predefined periods of time. By delivering pharmacologically high concentrations of active agents more selectively to pathological sites, drug delivery systems aim to improve the balance between efficacy and toxicity as compared to systemically administered therapeutics, thereby overcoming the shortcomings of systemic delivery of conventional drug formulations. This thesis describes the development of bone-specific delivery strategies either by linking bisphosphonates to drug delivery carriers or to chemotherapeutic platinum-based drugs. The drug delivery carriers were made of either inorganic or organic materials, and bisphosphonates were applied as the targeting moieties. These drug delivery systems were designed for use in local or non-local targeted delivery of chemotherapeutic platinum-based drugs to bone tumors.
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