Cannabis agonist injection effect on the coupling architecture in cortex of WAG/Rij rats during absence seizures

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Title:	Cannabis agonist injection effect on the coupling architecture in cortex of WAG/Rij rats during absence seizures
Author(s):	Sysoeva, M.V. ; Kuznetsova, G.D.; Rijn, C.M. van ; Sysoev, I.V.
Publication year:	2016
In:	Genina, E.A.; et al. (ed.), Proceedings of SPIE-The International Society for Optical Engineering, pp. art.nr.-99171X
Publisher:	Saratov : Russian Federation
DOI:	https://doi.org/10.1117/12.2225578
Annotation:	Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 21 september 2015
Publication type:	Article in monograph or in proceedings
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/159106
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Editor(s):	Genina, E.A.; et al.
Subject:	Biological psychology DI-BCB_DCC_Theme 3: Plasticity and Memory Biologische psychologie
Organization:	SW OZ DCC SMN
Book title:	Genina, E.A.; et al. (ed.), Proceedings of SPIE-The International Society for Optical Engineering
Issue:	iss. ; 9917
Page start:	p. art.nr.
Page end:	p. 99171X
Abstract:	WAG/Rij rats are well known genetic model of absence epilepsy, which is traditionally considered as a nonconvulsive generalised epilepsy of unknown aetiology. In current study the effect of (R)-(+)-WIN 55,212-2 (cannabis agonist) injection on the coupling between different parts of cortex was studied on 27 male 8 month old rats using local field potentials. Recently developed non-linear adapted Granger causality approach was used as a primary method. It was shown that first 2 hours after the injection the coupling between most channel pairs rises in comparison with the spontaneous activity, whilst long after the injection (2-6 hours) it drops down. The coupling increase corresponds to the mentioned before treatment effect, when the number and the longitude of seizures significantly decreases. However the subsequent decrease of the coupling in the cortex is accompanied by the dramatic increase of the longitude and the number of seizures. This assumes the hypothesis that a relatively higher coupling in the cortical network can prevent the seizure propagation and generalisation.
Languages used:	English (eng)