Connecting the dots, genome-wide association studies in substance use
until further notice
Number of pages
SourceMolecular Psychiatry, 21, 6, (2016), pp. 733-735
Article / Letter to editor
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SW OZ BSI OGG
The recent genome-wide association (GWA) meta-analysis of lifetime cannabis use by the International Cannabis Consortium marks a milestone in the study of the genetics of cannabis use. Similar milestones for the genetics of substance use were the GWA meta-analyses of four smoking related traits, of coffee consumption and of alcohol consumption. Combined, 315 981 partly overlapping individuals were genotyped, phenotyped and their data analyzed in genetic association studies, reflecting a huge communal effort by the substance use/addiction genetics community. These genome-wide association study (GWAS) efforts considered different stages of substance use: lifetime use (ever versus never use) was analyzed for cannabis and smoking, quantity of use (in users) was analyzed for coffee, alcohol, and smoking and age of initiation and cessation were analyzed for smoking.
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