Schematic memory components converge within angular gyrus during retrieval
Number of pages
SourceElife, 4, (2015), article e09668
Article / Letter to editor
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PI Group Memory and Emotion
SW OZ DCC CO
Subject130 000 Cognitive Neurology & Memory; Action, intention, and motor control; DI-BCB_DCC_Theme 2: Perception, Action and Control; Neuroinformatics; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience
Mental schemas form associative knowledge structures that can promote the encoding and consolidation of new and related information. Schemas are facilitated by a distributed system that stores components separately, presumably in the form of inter-connected neocortical representations. During retrieval, these components need to be recombined into one representation, but where exactly such recombination takes place is unclear. Thus, we asked where different schema components are neuronally represented and converge during retrieval. Subjects acquired and retrieved two well-controlled, rule-based schema structures during fMRI on consecutive days. Schema retrieval was associated with midline, medial-temporal, and parietal processing. We identified the multi-voxel representations of different schema components, which converged within the angular gyrus during retrieval. Critically, convergence only happened after 24-hour-consolidation and during a transfer test where schema material was applied to novel but related trials. Therefore, the angular gyrus appears to recombine consolidated schema components into one memory representation.
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