Cost-effectiveness of selective neck dissection versus modified radical neck dissection for treating metastases in patients with oral cavity cancer: A modelling study.

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Title:	Cost-effectiveness of selective neck dissection versus modified radical neck dissection for treating metastases in patients with oral cavity cancer: A modelling study.
Author(s):	Govers, T.M. ; Patel, S.; Takes, R.P. ; Merkx, T. ; Rovers, M.; Grutters, J.
Publication year:	2015
Source:	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, vol. 37, iss. 12, (2015), pp. 1762-1768
ISSN:	1043-3074
DOI:	https://doi.org/10.1002/hed.23833
Annotation:	1 december 2015
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/156928
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Subject:	Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences Radboudumc 9: Rare cancers RIHS: Radboud Institute for Health Sciences
Organization:	Oral and Maxillofacial Surgery Otorhinolaryngology
Journal title:	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume:	vol. 37
Issue:	iss. 12
Page start:	p. 1762
Page end:	p. 1768
Abstract:	BACKGROUND: Choosing between a more or less extensive neck dissection implies a tradeoff between survival, quality of life, and costs. The purpose of this study was to determine if selective neck dissection (level I-III or I-IV) is cost-effective compared with modified radical neck dissection (level I-V) in patients with cT1-2 oral squamous cell carcinoma (OSCC) with singular nodal disease confined to level I or II. METHODS: A decision-analytic model was developed to model quality-adjusted life years (QALYs) and costs over a lifetime horizon, based on literature. RESULTS: The selective neck dissection strategy resulted in an expected health loss of 0.06 QALY and savings of euro1351 per patient compared to modified radical neck dissection. The results were sensitive to differences in regional failure probabilities between the strategies. CONCLUSION: With the evidence used in this model, selective neck dissection was not cost-effective compared to modified radical neck dissection. Prospective research on regional failure is needed to provide optimal treatment for patients with OSCC. (c) 2015 Wiley Periodicals, Inc. Head Neck 37: 1762-1768, 2015.