A patient with a noninvasive mucinous ovarian borderline tumor presenting with late pleural metastases
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Publication year
2015Source
International Journal of Gynecological Pathology, 34, 2, (2015), pp. 143-50ISSN
Publication type
Article / Letter to editor
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Organization
Pathology
Cognitive Neuroscience
Gynaecology
Journal title
International Journal of Gynecological Pathology
Volume
vol. 34
Issue
iss. 2
Page start
p. 143
Page end
p. 50
Subject
Radboudumc 14: Tumours of the digestive tract RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 17: Women's cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 17: Women's cancers RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life SciencesAbstract
We describe a patient diagnosed with a noninvasive intestinal-type mucinous ovarian borderline tumor presenting with pleural metastases 4 yr later. This was confirmed by an identical mutation in TP53 in both tumors. Metastases of ovarian borderline tumors outside the pelvis or abdominal cavity are extremely rare. A large epidemiologic search in the Dutch Pathology Registry that was conducted in support of this case, identifying 1812 intestinal-type mucinous ovarian borderline tumors, suggests that microinvasion is associated with a higher risk of disease spread. Our case illustrates that intestinal-type mucinous ovarian borderline tumor with intraepithelial carcinoma might also have a higher risk of metastasis, assuming that microinvasion occurs in the presence of intraepithelial carcinoma. Both intraepithelial carcinoma and microinvasion could be a trigger for more extensive tumor sampling to prevent sampling error of (micro)invasive adenocarcinoma. In addition, this case draws attention to the developmental spectrum of Types I and II ovarian carcinomas. Borderline tumors harboring a TP53 mutation require further studying to examine whether they might develop into high-grade Type II carcinomas.
This item appears in the following Collection(s)
- Academic publications [238430]
- Electronic publications [122512]
- Faculty of Medical Sciences [90359]
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