Extensive Dissemination of Extended Spectrum beta-Lactamase-Producing Enterobacteriaceae in a Dutch Nursing Home
Publication year
2015Source
Infection Control and Hospital Epidemiology, 36, 4, (2015), pp. 394-400ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Primary and Community Care
Solid State Chemistry
Journal title
Infection Control and Hospital Epidemiology
Volume
vol. 36
Issue
iss. 4
Page start
p. 394
Page end
p. 400
Subject
Radboudumc 1: Alzheimer`s disease RIHS: Radboud Institute for Health SciencesAbstract
OBJECTIVE Risk factors for rectal carriage of ESBL-E and transmission were investigated in an outbreak of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E). DESIGN Rectal carriage of ESBL-E was determined in a cross-sectional survey by culture of perianal swabs or fecal samples. Both phenotypical and genotypical methods were used to detect the production of ESBL. Nosocomial transmission was defined as the presence of genotypically related strains in >/=2 residents within the NH. Patient characteristics and variables in infection control practices were registered to investigate risk factors for transmission. SETTING A nursing home (NH) in the southern Netherlands. PARTICIPANTS Of 189 residents, 160 residents (84.7%) were screened for ESBL-E carriage. Of these 160 residents, 33 (20.6%) were ESBL-E positive. ESBL carriage rates varied substantially between wards (range, 0-47%). Four different ESBL-E clusters were observed. A bla CTX-M1-15 positive E. coli ST131 constituted the largest cluster (n=21) and was found in multiple wards (n=7). RESULTS Our investigation revealed extensive clonal dissemination of bla CTX-M1-15-positive E. coli ST131 in a nursing home. Unexplained differences in ESBL prevalence were detected among the wards. CONCLUSIONS As NHs constitute potential sources of multidrug-resistant bacteria, it is important to gain a better understanding of the risks factors and routes of transmission of ESBL-E. Infect Control Hosp Epidemiol 2014;00(0): 1-7.
This item appears in the following Collection(s)
- Academic publications [227613]
- Faculty of Medical Sciences [86193]
- Faculty of Science [33762]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.