Dietary nucleotide and nucleoside exposure in infancy and atopic dermatitis, recurrent wheeze, and allergic sensitization

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Title:	Dietary nucleotide and nucleoside exposure in infancy and atopic dermatitis, recurrent wheeze, and allergic sensitization
Author(s):	Timmermans, M.J.C. ; Dagnelie, P.C.; Theunisz, E.H.; Ewalds, D.; Thijs, C.; Mommers, M.; Arts, I.C.
Publication year:	2015
Source:	Journal of Pediatric Gastroenterology and Nutrition, vol. 60, iss. 5, (2015), pp. 691-693
ISSN:	0277-2116
DOI:	https://doi.org/10.1097/MPG.0000000000000689
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/155015
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Subject:	Radboudumc 18: Healthcare improvement science RIHS: Radboud Institute for Health Sciences
Organization:	IQ Healthcare
Journal title:	Journal of Pediatric Gastroenterology and Nutrition
Volume:	vol. 60
Issue:	iss. 5
Page start:	p. 691
Page end:	p. 693
Abstract:	We hypothesized that early life exposure to nucleotides and nucleosides lowers the risk of recurrent wheeze, atopic dermatitis, and allergic sensitization among n = 429 children. Concentrations in breast milk were established by high-performance liquid chromatography; concentrations in formula milks were obtained from manufacturers. Questionnaires and home visits were used to assess outcomes. Adjusted odds ratios in the highest tertile compared with those in the lowest tertile of exposure ranged from 1.11 to 1.99 in predominantly formula-fed children, and from 0.40 to 0.53 in predominantly breast-fed children, but were not significant. Thus, we found no evidence for association between nucleotide and nucleoside exposure and the development of atopic outcomes in children up to 2 years.