Calibrated MRI to evaluate cerebral hemodynamics in patients with an internal carotid artery occlusion
SourceJournal of Cerebral Blood Flow and Metabolism, 35, 6, (2015), pp. 1015-23
Article / Letter to editor
Display more detailsDisplay less details
Journal of Cerebral Blood Flow and Metabolism
SubjectRadboudumc 3: Disorders of movement DCMN: Donders Center for Medical Neuroscience
The purpose of this study was to assess whether calibrated magnetic resonance imaging (MRI) can identify regional variances in cerebral hemodynamics caused by vascular disease. For this, arterial spin labeling (ASL)/blood oxygen level-dependent (BOLD) MRI was performed in 11 patients (65+/-7 years) and 14 controls (66+/-4 years). Cerebral blood flow (CBF), ASL cerebrovascular reactivity (CVR), BOLD CVR, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) were evaluated. The CBF was 34+/-5 and 36+/-11 mL/100 g per minute in the ipsilateral middle cerebral artery (MCA) territory of the patients and the controls. Arterial spin labeling CVR was 44+/-20 and 53+/-10% per 10 mm Hg triangle upEtCO2 in patients and controls. The BOLD CVR was lower in the patients compared with the controls (1.3+/-0.8 versus 2.2+/-0.4% per 10 mm Hg triangle upEtCO2, P<0.01). The OEF was 41+/-8% and 38+/-6%, and the CMRO2 was 116+/-39 and 111+/-40 mumol/100 g per minute in the patients and the controls. The BOLD CVR was lower in the ipsilateral than in the contralateral MCA territory of the patients (1.2+/-0.6 versus 1.6+/-0.5% per 10 mmHg triangle upEtCO2, P<0.01). Analysis was hampered in three patients due to delayed arrival time. Thus, regional hemodynamic impairment was identified with calibrated MRI. Delayed arrival artifacts limited the interpretation of the images in some patients.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.