Subject:
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Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences |
Organization:
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Primary and Community Care |
Journal title:
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Journal of Addiction Medicine
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Abstract:
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Baclofen is a gamma-aminobutyric acid (GABA)-beta receptor agonist with a muscle relaxant effect. It increases GABA activity and reduces the production of glutamate and dopamine. The GABA precursor gamma-hydroxybutyrate (GHB) has gained popularity as a drug of abuse. For the first time, we report a case of a GHB-dependent patient, who ingested several days' doses of baclofen (80 mg) simultaneously with 0.3 L (215 g) of illicit GHB. Baclofen (40 mg/d) was prescribed to prevent relapse after a successful detoxification. The patient developed a rapid coma (E2M5V1 with oxygen support), bradypnea, and hypotonia. Physicians should be alert to the danger of this combination because of the hazards of coma and respiratory distress.
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