Transient relay function of midline thalamic nuclei during long-term memory consolidation in humans
Publication year
2015Number of pages
5 p.
Source
Learning & Memory, 22, 10, (2015), pp. 527-531ISSN
Publication type
Article / Letter to editor
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Organization
PI Group MR Techniques in Brain Function
Donders Centre for Cognitive Neuroimaging
Psychiatry
Cognitive Neuroscience
PI Group Memory & Emotion
Journal title
Learning & Memory
Volume
vol. 22
Issue
iss. 10
Languages used
English (eng)
Page start
p. 527
Page end
p. 531
Subject
130 000 Cognitive Neurology & Memory; 150 000 MR Techniques in Brain Function; Learning and Plasticity; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical NeuroscienceAbstract
To test the hypothesis that thalamic midline nuclei play a transient role in memory consolidation, we reanalyzed a prospective functional MRI study, contrasting recent and progressively more remote memory retrieval. We revealed a transient thalamic connectivity increase with the hippocampus, the medial prefrontal cortex (mPFC), and a parahippocampal area, which decreased with time. In turn, mPFC-parahippocampal connectivity increased progressively. These findings support a model in which thalamic midline nuclei serve as a hub linking hippocampus, mPFC, and posterior representational areas during memory retrieval at an early (2 h) stage of consolidation, extending classical systems consolidation models by attributing a transient role to midline thalamic nuclei.
This item appears in the following Collection(s)
- Academic publications [238441]
- Donders Centre for Cognitive Neuroimaging [3824]
- Electronic publications [122544]
- Faculty of Medical Sciences [90373]
- Open Access publications [97535]
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