Transient relay function of midline thalamic nuclei during long-term memory consolidation in humans
Number of pages
SourceLearning & Memory, 22, 10, (2015), pp. 527-531
Article / Letter to editor
Display more detailsDisplay less details
PI Group MR Techniques in Brain Function
Donders Centre for Cognitive Neuroimaging
PI Group Memory & Emotion
Learning & Memory
Subject130 000 Cognitive Neurology & Memory; 150 000 MR Techniques in Brain Function; Learning and Plasticity; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical Neuroscience
To test the hypothesis that thalamic midline nuclei play a transient role in memory consolidation, we reanalyzed a prospective functional MRI study, contrasting recent and progressively more remote memory retrieval. We revealed a transient thalamic connectivity increase with the hippocampus, the medial prefrontal cortex (mPFC), and a parahippocampal area, which decreased with time. In turn, mPFC-parahippocampal connectivity increased progressively. These findings support a model in which thalamic midline nuclei serve as a hub linking hippocampus, mPFC, and posterior representational areas during memory retrieval at an early (2 h) stage of consolidation, extending classical systems consolidation models by attributing a transient role to midline thalamic nuclei.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.