Restoring immunosurveillance by dendritic cell vaccines and manipulation of the tumor microenvironment
Publication year
2015Source
Immunobiology, 220, 2, (2015), pp. 243-248ISSN
Publication type
Article / Letter to editor
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Organization
Tumorimmunology
Medical Oncology
Journal title
Immunobiology
Volume
vol. 220
Issue
iss. 2
Page start
p. 243
Page end
p. 248
Subject
Radboudumc 17: Women's cancers RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Cancer cells evolve from normal cells throughout life and are usually recognized by our immune system and destroyed, a process called immunosurveillance. Unfortunately, in some instances cancer cells paralyze our immune system, resulting in outgrowth and spreading of the tumor. Understanding the complexity of immunomodulation by tumors is important for the development of therapeutical strategies. Nowadays, various approaches have been developed to enhance anti-tumor immune responses and abrogate the immune dampening effect of the tumor and its surrounding environment, including dendritic cell-based vaccines, therapies to counteract myeloid derived suppressor cell function within the tumor and antagonists of inhibitory signaling pathways to overcome 'immune checkpoints'. The challenge is now to find the right combination of immune based therapies to fully restore immune function and provide a more efficacious and enduring anti-tumor response.
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- Academic publications [238441]
- Electronic publications [122523]
- Faculty of Medical Sciences [90373]
- Open Access publications [97518]
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