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Publication year
2015Author(s)
Number of pages
8 p.
Source
Stroke, 46, 2, (2015), pp. 425-432ISSN
Publication type
Article / Letter to editor

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Organization
Donders Centre for Cognitive Neuroimaging
Cognitive Neuroscience
PI Group MR Techniques in Brain Function
Neurology
Journal title
Stroke
Volume
vol. 46
Issue
iss. 2
Languages used
English (eng)
Page start
p. 425
Page end
p. 432
Subject
150 000 MR Techniques in Brain Function; Radboudumc 3: Disorders of movement DCMN: Donders Center for Medical NeuroscienceAbstract
BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are associated with clinically heterogeneous symptoms that cannot be explained by these lesions alone. It is hypothesized that these lesions are associated with distant cortical atrophy and cortical thickness network measures, which can result in an additional cognitive impairment. Here, we investigated the relationships between WMH, cortical thickness, and cognition in subjects with cerebral small vessel disease. METHODS: A total of 426 subjects with cerebral small vessel disease were included, aged between 50 and 85 years, without dementia, and underwent MRI scanning. Cortical thickness analysis was performed, and WMH were manually segmented. Graph theory was applied to examine the relationship between network measures and WMH, and structural covariance matrices were constructed using inter-regional cortical thickness correlations. RESULTS: Higher WMH load was related to lower cortical thickness in frontotemporal regions, whereas in paracentral regions, this was related to higher cortical thickness. Network analyses revealed that measures of network disruption were associated with WMH and cognitive performance. Furthermore, WMH in specific white matter tracts were related to regional-specific cortical thickness and network measures. Cognitive performances were related to cortical thickness in frontotemporal regions and network measures, and not to WMH, while controlling for cortical thickness. CONCLUSIONS: These cross-sectional results suggest that cortical changes (regional-specific damage and network breakdown), mediated (in)directly by WMH (tract-specific damage) and other factors (eg, vascular risk factors), might lead to cognitive decline. These findings have implications in understanding the relationship between WMH, cortical morphology, and the possible attendant cognitive decline and eventually dementia.
This item appears in the following Collection(s)
- Academic publications [205116]
- Donders Centre for Cognitive Neuroimaging [3442]
- Electronic publications [103350]
- Faculty of Medical Sciences [81054]
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