Prescribing patterns of antenatal corticosteroids in women with threatened preterm labor

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Title:	Prescribing patterns of antenatal corticosteroids in women with threatened preterm labor
Author(s):	Wilms, F.F.; Baaren, G.J. van; Vis, J.Y.; Oudijk, M.A.; Kwee, A.; Porath, M.M.; Scheepers, H.C.; Spaanderman, M.E.; Bloemenkamp, K.W.; Bolte, A.C. ; Bax, C.J.; Cornette, J.M.; Duvekot, J.J.; Bijvank, B.W. Nij; Eyck, J. van; Franssen, M.T.; Sollie, K.M.; Vandenbussche, F.P.H.A. ; Woiski, M.D. ; Post, J.A. van der; Bossuyt, P.M.; Opmeer, B.C.; Mol, B.W.
Publication year:	2015
Source:	European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 192, (2015), pp. 47-53
ISSN:	0301-2115
DOI:	https://doi.org/10.1016/j.ejogrb.2015.06.008
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/153709
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Subject:	Radboudumc 0: Other Research RIHS: Radboud Institute for Health Sciences Radboudumc 10: Reconstructive and regenerative medicine RIMLS: Radboud Institute for Molecular Life Sciences
Organization:	Gynaecology
Journal title:	European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume:	vol. 192
Page start:	p. 47
Page end:	p. 53
Abstract:	OBJECTIVE: To assess the impact of cervical length (CL) measurement and fetal fibronectin testing (fFN) on the clinicians' decision to prescribe antenatal corticosteroids (ACS) to women with symptoms of preterm labor. STUDY DESIGN: This is a secondary analysis of a prospective cohort study including women with symptoms of preterm labor and intact membranes between 24 and 34 weeks' gestation. We compared the proportion prescribed and completed ACS courses, preterm delivery within seven days and median intervals from ACS to delivery in four groups: group 1 CL<10mm, group 2 CL 10-30mm and positive fFN, group 3 CL 10-30mm and negative fFN, group 4 CL>30mm. RESULTS: ACS were prescribed to 63/65 (97%) women in group 1, 176/192 (91%) in group 2, 111/172 women (65%) in group 3 and 55/242 (23%) in group 4. In group 1, 42 (65%) women delivered within seven days, compared to 34 (18%) in group 2, 6 (3%) in group 3 and 3 (1%) in group 4. Median intervals between ACS and delivery were 6 days (IQR 3-61 days), 44 days (IQR 17-69 days), 53 days (IQR 37-77 days) and 66 days (IQR 43-78 days) in group 1, 2, 3 and 4 respectively. CONCLUSION: ACS were prescribed frequently to women with a CL of 10-30mm and a negative fFN test or a CL>30mm. There is room for improvement in the prescription of ACS in these low risk women.