Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
SourceNature Neuroscience, 18, 7, (2015), pp. 953-955
Article / Letter to editor
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SubjectRadboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
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