Olfactory receptor genes cooperate with protocadherin genes in human extreme obesity
Publication year
2015Source
Genes and Nutrition, 10, 4, (2015), pp. 465ISSN
Publication type
Article / Letter to editor
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Organization
CMBI
Journal title
Genes and Nutrition
Volume
vol. 10
Issue
iss. 4
Page start
p. 465
Subject
Radboudumc 6: Metabolic Disorders RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Worldwide, the incidence of obesity has increased dramatically over the past decades. More knowledge about the complex etiology of obesity is needed in order to find additional approaches for treatment and prevention. Investigating the exome sequencing data of 30 extremely obese subjects (BMI 45-65 kg/m(2)) shows that predicted damaging missense variants in olfactory receptor genes on chromosome 1q and rare predicted damaging variants in the protocadherin (PCDH) beta-cluster genes on chromosome 5q31, reported in our previous work, co-localize in subjects with extreme obesity. This implies a synergistic effect between genetic variation in these gene clusters in the predisposition to extreme obesity. Evidence for a general involvement of the olfactory transduction pathway on itself could not be found. Bioinformatic analysis indicates a specific involvement of the PCDH beta-cluster genes in controlling tissue development. Further mechanistic insight needs to await the identification of the ligands of the 1q olfactory receptors. Eventually, this may provide the possibility to manipulate food flavor in a way to reduce the risk of overeating and of extreme obesity in genetically predisposed subjects.
This item appears in the following Collection(s)
- Academic publications [238586]
- Electronic publications [122804]
- Faculty of Medical Sciences [90409]
- Open Access publications [97790]
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