Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method
Publication year
2015Source
Antimicrobial Agents and Chemotherapy, 59, 1, (2015), pp. 666-8ISSN
Publication type
Article / Letter to editor

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Organization
Medical Microbiology
Journal title
Antimicrobial Agents and Chemotherapy
Volume
vol. 59
Issue
iss. 1
Page start
p. 666
Page end
p. 8
Subject
Radboudumc 4: lnfectious Diseases and Global Health RIHS: Radboud Institute for Health SciencesAbstract
Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 mug/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.
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- Academic publications [233356]
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- Faculty of Medical Sciences [89145]
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