Medial prefrontal-hippocampal connectivity and motor memory consolidation in depression and schizophrenia
Publication year
2015Author(s)
Number of pages
10 p.
Source
Biological Psychiatry, 77, 2, (2015), pp. 177-186ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
PI Group Memory & Emotion
Cognitive Neuroscience
Journal title
Biological Psychiatry
Volume
vol. 77
Issue
iss. 2
Languages used
English (eng)
Page start
p. 177
Page end
p. 186
Subject
130 000 Cognitive Neurology & Memory; Neuroinformatics; Radboudumc 13: Stress-related disorders DCMN: Donders Center for Medical NeuroscienceAbstract
BACKGROUND: Overnight memory consolidation is disturbed in both depression and schizophrenia, creating an ideal situation to investigate the mechanisms underlying sleep-related consolidation and to distinguish disease-specific processes from common elements in their pathophysiology. METHODS: We investigated patients with depression and schizophrenia, as well as healthy control subjects (each n = 16), under a motor memory consolidation protocol with functional magnetic resonance imaging and polysomnography. RESULTS: In a sequential finger-tapping task associated with the degree of hippocampal-prefrontal cortex functional connectivity during the task, significantly less overnight improvement was identified as a common deficit in both patient groups. A task-related overnight decrease in activation of the basal ganglia was observed in control subjects and schizophrenia patients; in contrast, patients with depression showed an increase. During the task, schizophrenia patients, in comparison with control subjects, additionally recruited adjacent cortical areas, which showed a decrease in functional magnetic resonance imaging activation overnight and were related to disease severity. Effective connectivity analyses revealed that the hippocampus was functionally connected to the motor task network, and the cerebellum decoupled from this network overnight. CONCLUSIONS: While both patient groups showed similar deficits in consolidation associated with hippocampal-prefrontal cortex connectivity, other activity patterns more specific for disease pathology differed.
This item appears in the following Collection(s)
- Academic publications [245348]
- Donders Centre for Cognitive Neuroimaging [4022]
- Electronic publications [132789]
- Faculty of Medical Sciences [93207]
- Open Access publications [106326]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.