RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Publication year
2015Source
Cancer Cell, 28, 5, (2015), pp. 666-76ISSN
Publication type
Article / Letter to editor

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Organization
Pathology
Journal title
Cancer Cell
Volume
vol. 28
Issue
iss. 5
Page start
p. 666
Page end
p. 76
Subject
Radboudumc 9: Rare cancers RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-positive, and mutant KRAS, EGFR, or PIK3CA tumors were accurately distinguished using surrogate TEP mRNA profiles. Our results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based "liquid biopsies".
This item appears in the following Collection(s)
- Academic publications [202606]
- Electronic publications [100803]
- Faculty of Medical Sciences [79948]
- Open Access publications [69538]
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