Optimized (31) P MRS in the human brain at 7 T with a dedicated RF coil setup
SourceNMR in Biomedicine, 28, 11, (2015), pp. 1570-8
Article / Letter to editor
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NMR in Biomedicine
SubjectRadboudumc 15: Urological cancers RIHS: Radboud Institute for Health Sciences; Radboudumc 19: Nanomedicine RIMLS: Radboud Institute for Molecular Life Sciences
The design and construction of a dedicated RF coil setup for human brain imaging ((1) H) and spectroscopy ((31) P) at ultra-high magnetic field strength (7 T) is presented. The setup is optimized for signal handling at the resonance frequencies for (1) H (297.2 MHz) and (31) P (120.3 MHz). It consists of an eight-channel (1) H transmit-receive head coil with multi-transmit capabilities, and an insertable, actively detunable (31) P birdcage (transmit-receive and transmit only), which can be combined with a seven-channel receive-only (31) P array. The setup enables anatomical imaging and (31) P studies without removal of the coil or the patient. By separating transmit and receive channels and by optimized addition of array signals with whitened singular value decomposition we can obtain a sevenfold increase in SNR of (31) P signals in the occipital lobe of the human brain compared with the birdcage alone. These signals can be further enhanced by 30 +/- 9% using the nuclear Overhauser effect by B1 -shimmed low-power irradiation of water protons. Together, these features enable acquisition of (31) P MRSI at high spatial resolutions (3.0 cm(3) voxel) in the occipital lobe of the human brain in clinically acceptable scan times (~15 min). (c) 2015 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.
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