Interferon-gamma immunotherapy in a patient with refractory disseminated candidiasis
until further notice
SourcePediatric Infectious Disease Journal, 34, 12, (2015), pp. 1391-4
Article / Letter to editor
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Pediatric Infectious Disease Journal
SubjectRadboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences
Despite advances in supportive care and novel antifungal agents, mortality due to invasive Candida infection is high. Athree-year-old boy with disseminatedC.dubliniensis infection during induction chemotherapy for acute lymphoblastic leukemiadeteriorated despite resolution of neutropenia and appropriate antifungal treatment. Monocyte HLA-DR-expression was extremely low, suggesting immunoparalysis. Adjuvant immunotherapy with IFN-gamma restored the immune response, which was accompanied by clinical and radiographic recovery.
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