Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males.
Publication year
2015Source
European Journal of Preventive Cardiology, 22, 8, (2015), pp. 1083-7ISSN
Annotation
01 augustus 2015
Publication type
Article / Letter to editor

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Organization
Physiology
Journal title
European Journal of Preventive Cardiology
Volume
vol. 22
Issue
iss. 8
Page start
p. 1083
Page end
p. 7
Subject
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health SciencesAbstract
BACKGROUND: Ischaemic preconditioning has well-established cardiac and vascular protective effects. Short interventions (one week) of daily ischaemic preconditioning episodes improve conduit and microcirculatory function. This study examined whether a longer (eight weeks) and less frequent (three per week) protocol of repeated ischaemic preconditioning improves vascular function. METHODS: Eighteen males were randomly allocated to either ischaemic preconditioning (22.4 +/- 2.3 years, 23.7 +/- 3.1 kg/m(2)) or a control intervention (26.0 +/- 4.8 years, 26.4 +/- 1.9 kg/m(2)). Brachial artery endothelial-dependent (FMD), forearm cutaneous microvascular function and cardiorespiratory fitness were assessed at zero, two and eight weeks. RESULTS: A greater improvement in FMD was evident following ischaemic preconditioning training compared with control at weeks 2 (2.24% (0.40, 4.08); p=0.02) and 8 (1.11% (0.13, 2.10); p=0.03). Repeated ischaemic preconditioning did not change cutaneous microcirculatory function or fitness. CONCLUSIONS: These data indicate that a feasible and practical protocol of regular ischaemic preconditioning episodes improves endothelial function in healthy individuals within two weeks, and these effects persist following repeated ischaemic preconditioning for eight weeks.
This item appears in the following Collection(s)
- Academic publications [227587]
- Faculty of Medical Sciences [87012]
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