Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males.
SourceEuropean Journal of Preventive Cardiology, 22, 8, (2015), pp. 1083-7
01 augustus 2015
Article / Letter to editor
Display more detailsDisplay less details
European Journal of Preventive Cardiology
SubjectRadboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences
BACKGROUND: Ischaemic preconditioning has well-established cardiac and vascular protective effects. Short interventions (one week) of daily ischaemic preconditioning episodes improve conduit and microcirculatory function. This study examined whether a longer (eight weeks) and less frequent (three per week) protocol of repeated ischaemic preconditioning improves vascular function. METHODS: Eighteen males were randomly allocated to either ischaemic preconditioning (22.4 +/- 2.3 years, 23.7 +/- 3.1 kg/m(2)) or a control intervention (26.0 +/- 4.8 years, 26.4 +/- 1.9 kg/m(2)). Brachial artery endothelial-dependent (FMD), forearm cutaneous microvascular function and cardiorespiratory fitness were assessed at zero, two and eight weeks. RESULTS: A greater improvement in FMD was evident following ischaemic preconditioning training compared with control at weeks 2 (2.24% (0.40, 4.08); p=0.02) and 8 (1.11% (0.13, 2.10); p=0.03). Repeated ischaemic preconditioning did not change cutaneous microcirculatory function or fitness. CONCLUSIONS: These data indicate that a feasible and practical protocol of regular ischaemic preconditioning episodes improves endothelial function in healthy individuals within two weeks, and these effects persist following repeated ischaemic preconditioning for eight weeks.
This item appears in the following Collection(s)
- Academic publications 
- Faculty of Medical Sciences 
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.