Characterizing brain oscillations in cognition and disease
Publication year
2016Author(s)
Publisher
[S.l.] : [S.n.]
ISBN
9789462840379
Number of pages
136 p.
Annotation
Radboud Universiteit Nijmegen, 13 januari 2016
Promotor : Jensen, O. Co-promotor : Gerven, M.A.J. van
Publication type
Dissertation

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Organization
PI Group Neuronal Oscillations
Subject
NeuroinformaticsAbstract
It has been suggested that neuronal oscillations play a fundamental role for shaping the functional architecture of the working brain. This thesis investigates brain oscillations in rat, human healthy population and major depressive disorder (MDD) patients. A novel measurement termed cross-frequency directionality is developed to assess the directional interaction between slow and fast oscillations. The results suggest that bidirectional communication - the fast oscillations coordinating the slow oscillations, or vice versa - are both possible. Overall, this indicates that the brain coordinates information flow in a complex and flexibie manner. Moreover, disrupted brain oscillations are identified in MDD patients in comparison to healthy controls. Furthermore, information about patients’ brain oscillations information and an advanced machine learning technology are integrated to predict MDD depression severity. The proposed model could yield a quantitative and objective estimation for depression severity, which in turn has the potential to help psychiatrists with more precise diagnosis, earlier detection, better prevention, and treatment effect evaluation on MDD.
This item appears in the following Collection(s)
- Academic publications [202914]
- Dissertations [12257]
- Donders Centre for Cognitive Neuroimaging [3357]
- Electronic publications [101090]
- Open Access publications [69750]
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