Injectable In Situ Forming Hybrid Iron Oxide-Hyaluronic Acid Hydrogel for Magnetic Resonance Imaging and Drug Delivery

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Publication year
2014Source
Macromolecular Bioscience, 14, (2014), pp. 1249-1259ISSN
Publication type
Article / Letter to editor

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Organization
Neurophysiology
Medical Imaging
Dentistry
Journal title
Macromolecular Bioscience
Volume
vol. 14
Page start
p. 1249
Page end
p. 1259
Subject
Radboudumc 10: Reconstructive and regenerative medicine RIHS: Radboud Institute for Health Sciences; Radboudumc 15: Urological cancers RIMLS: Radboud Institute for Molecular Life SciencesAbstract
The development of multimodal in situ cross-linkable hyaluronic acid nanogels hybridized with iron oxide nanoparticles is reported. Utilizing a chemoselective hydrazone coupling reaction, the nanogels are converted to a macroscopic hybrid hydrogel without any additional reagent. Hydrophobic cargos remain encapsulated in the hydrophobic domains of the hybrid hydrogel without leakage. However, hydrogel degradation with hyaluronidase liberates iron oxide nanoparticles. This allows the utilization of imaging agents as tracers of the hydrogel degradation. UV-vis spectrometry and MRI studies reveal that the degradability of the hydrogels correlates with their structure. The hydrogels presented here are very promising theranostic tools for hyaluronidase-mediated delivery of hydrophobic drugs, as well as imaging of hydrogel degradation and tracking of degradation products in vivo.
This item appears in the following Collection(s)
- Academic publications [227613]
- Electronic publications [107286]
- Faculty of Medical Sciences [86193]
- Faculty of Science [33762]
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